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What Smells do Mice Hate – Natural Repellents that Work

Posted by Emma Grace Crumbley, Entomologist

February 4, 2026

What Smells do Mice Hate – Natural Repellents that Work

If you read our latest blog on pest misconceptions, you learned that, unlike the cartoons, mice don't actually love cheese. While they'll eat cheese if it’s available, they mostly prefer carbohydrate-rich foods such as grains, seeds, crackers, and cereals. Mice can track down food sources and find entry points into our homes thanks to their exceptional sense of smell. And unlike rats, mice are not neophobic – they are highly curious and motivated by exploration, foraging, and survival.

When looking for a natural repellent to try against mice, a few scents have a track record of repelling them. However, these natural agents really only provide short-term solutions to mouse problems, and each one has its own drawback:

Ammonia – is regularly cited as a mouse deterrent. To us, ammonia might smell like rotting fish, but to mice, ammonia closely resembles the smell of predators (specifically their urine). Some people leave out a small dish of ammonia near mouse entry points.

Pros: Cheap, easy to apply, strong odor.

Cons: Highly toxic to children and pets, requires reapplications, makes your home smell…

Cayenne Pepper and Garlic – Some sources suggest making sachets of spicy herbs, such as cayenne pepper and garlic, to deter mice. These herbs have especially strong odors that interfere with and overwhelm a mouse's sense of smell. 

Pros: Cheap, easy to apply, more pleasant aroma than ammonia

Cons: Requires frequent reapplication, as herbs can lose potency within 24-72 hours.

Peppermint Oil – This is probably the frontrunner of our natural repellent list. Peppermint oil is cited in many reputable sources for its repellent nature against a variety of pests, including insects and rodents. The overwhelming odor of peppermint is irritating to mice, and daily applications at high concentrations yield the best repellency.

Pros: Easy to apply, proven effectiveness from reliable sources

Cons: Requires frequent reapplication and can be a skin, nose, and eye irritant when used at high concentrations.

Predators – As crazy as it sounds, having cats and birds around actually does affect whether mice will want to explore your home and yard. Natural predators release scents like hormones, skin odors, and proteins secreted in saliva, urine, and sweat that can linger and repel nearby mice.

Pros: Hands-free solution if you have indoor cats or natural predators in your yard.

Cons: Not effective for people with cat allergies or in densely urban areas with less predator activity.

Vinegar – has a strong, sharp smell that can repel mice and other insect pests. Some people leave rags soaked in vinegar near entry points, while others spray vinegar-water mixtures along baseboards and kitchen cabinets.

Pros: Cheap, easy to apply, and fairly odorless to us.

Cons: Requires regular reapplications as vinegar evaporates quickly.

Natural scents and repellents can work for short-term strategies. However, for long-term mouse control and prevention, focus on finding and sealing the entry points mice are using to get inside and increasing sanitation in kitchens and trash areas. Making small changes, like keeping a clean kitchen and removing gaps around doors, can have a huge impact on any rodent problems you may be dealing with.

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Emma Grace Crumbley

Emma Grace Crumbley

Entomologist

Emma Grace Crumbley, also known as Emma the Entomologist, is a University of Georgia-trained expert with degrees in Applied Biotechnology and Entomology. As part of the Mosquito Squad team, she shares engaging insights on mosquitoes, ticks, and other pests through blogs, videos, and social media, aiming to make insect education accessible and reduce fear around bugs.