“Publishing online July 14 in the journal Science, Johns Hopkins Bloomberg School of Public Health researchers say that despite the discovery of Zika in Uganda in 1947 and the identification of the first confirmed human infection in Nigeria six years later, few cases were reported in humans until 2007. Even then, no one understood the grave risk the disease posed to pregnancies until the recent outbreak in Brazil, which began less than two years ago.
“’The rise of Zika after its long persistence as a disease of apparently little importance highlights how little we truly understand about the global spread of mosquito-borne viruses and other lesser known diseases,’ says Justin Lessler, an associate professor of epidemiology at the Bloomberg School who led the study along with Lelia Chaisson, a student in the department. ‘Over the past decades, dengue, chikungunya, West Nile virus and now Zika have emerged or re-emerged across the globe. Yet why these viruses have expanded their range and others have failed to invade areas potentially ripe for their spread remains a mystery.’
“In their review article, Lessler and his colleagues looked at previously published research on Zika in an attempt to assess the global threat the virus poses. Many of the questions raised thus far by the recent outbreak, which has hit hard in Brazil, Colombia, Puerto Rico and other parts of the Americas, still need to be answered.
“There are two main theories as to why Zika is currently posing such a threat: that the virus has mutated to become more infectious or pathogenic, or that it previously struck such small populations that it was hard to discern its health effects.”
“When an outbreak in French Polynesia from October 2013 to April 2014 infected an estimated 66 percent of the population, the number of cases of Guillain-Barre syndrome jumped dramatically (from three to 42), but the small number of people made it difficult to be sure of the cause and effect. Only later did it become apparent that there may also have been an increase in cases of microcephaly – a condition where a baby’s head and brain can be dangerously small – over the same period. Most people who are infected either show no symptoms or minor ones like rashes.
“But these links became clear once Zika moved to Brazil, with its population of 200 million. It spread rapidly because this was a population that had never before been exposed to this virus, and there was no immunity.
“’Despite knowing about this disease for nearly 70 years, we were completely surprised and rushing to discover the very basic things about it when it invaded the Americas,’ Lessler says. ‘We have been completely unable to stop its spread. That is a problem for how we approach public health. We will always be in this situation when something new comes about or something little-known reemerges unless we do a better job planning for threats more generally instead of always fighting the last battle.’”